Modulating cGMP in heart failure by novel natriuretic peptides
نویسنده
چکیده
We recently reported the design, synthesis and biological actions of a novel chimeric natriuretic peptide (NP) fusing the 22-amino acid (AA) sequence of mature C-type natriuretic peptide (CNP), a member of the NP family that is highly conserved among species, with the 15-AA C-terminus of Dendroaspis natriuretic peptide (DNP) that was isolated from the venom of the eastern green mamba snake (Dendroaspis angusticeps).
منابع مشابه
Endogenous natriuretic peptides participate in renal and humoral actions of acute vasopeptidase inhibition in experimental mild heart failure.
Mild heart failure is characterized by increases in atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in the absence of activation of the renin-angiotensin-aldosterone system (RAAS). Vasopeptidase (VP) inhibitors are novel molecules that coinhibit neutral endopeptidase 24.11, which degrades the natriuretic peptides (NPs) and ACE. In a well-characterized canine model of mild h...
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A hallmark of overt congestive heart failure (CHF) is attenuated cGMP production by endogenous atrial natriuretic peptide (ANP) with renal resistance to ANP. ANP and brain natriuretic peptides (BNP) are of myocardial origin, whereas urodilatin (Uro) is thought to be derived from kidney. All three peptides are agonists to the natriuretic peptide-A receptor. Our objective was to compare the cardi...
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BACKGROUND Screening for patients with asymptomatic left ventricular dysfunction is of considerable importance because they may benefit from early treatment with angiotensin converting enzyme inhibitors. It has been suggested that atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and cyclic guanosine 3',5'-monophosphate (cGMP) might be useful markers for screening. OBJECTIVE ...
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Natriuretic peptides are a family of structurally related but genetically distinct hormones/paracrine factors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. The mammalian members are atrial natriuretic peptide, B-type natriuretic peptide, C-type natriuretic peptide, and possibly osteocrin/musclin. Three single m...
متن کاملTRANSLATIONAL PHYSIOLOGY Equimolar doses of atrial and brain natriuretic peptides and urodilatin have differential renal actions in overt experimental heart failure
Chen, Horng H., Alessandro Cataliotti, John A. Schirger, Fernando L. Martin, and John C. Burnett, Jr. Equimolar doses of atrial and brain natriuretic peptides and urodilatin have differential renal actions in overt experimental heart failure. Am J Physiol Regul Integr Comp Physiol 288: R1093–R1097, 2005. First published December 30, 2004; doi:10.1152/ajpregu.00682.2004.—A hallmark of overt cong...
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